Endocrine Abstracts

Introduction: Parathyroid hormone (PTH) secretion is regulated by the concentration of extracellular ionized calcium. The calcium sensing receptors (CaSR) of parathyroid chief cells play a central role in calcium homeostasis. Their activity is reduced by calcimimetics, the compounds that directly increase the sensitivity of CaSR to extracellular ionized calcium. Cinacalcet hydrochloride, an oral calcimimetic, is indicated in treatment of primary hyperparathyroidism (PHP), for ...

Background: Pituitary prolactin secretion is physiologically supressed by dopaminergic tonus from hypothalamus, which itself is under regulation by various hypothalamic releasing factors. We Disturbed dopaminergic tonus in patients with liver cirrhosis is suspected.The aim of our study was to measure prolactin levels in patients with cirrhosis and to investigate the relatioship between the severity of liver disease and other clinical and laboratory param...

Currently, acromegaly is treatable by 3 groups of drugs available for the treatment of acromegaly: dopamine agonists (DA), somatostatin analogues (SRL) and a growth hormone receptor blocker (GH receptor antagonist GHRA). More recently, pasireotide and pasireotide-LAR were developed as multi-receptor targeted SRLs with higher potency than 1st generation SRLs/octreotide-LAR and lanreotide/and until now were considered second generation SRLs. Pasireotide, unlike first-generation ...

Background: The coronavirus disease 2019 (COVID-19) pandemic led to changes in lifestyle, which could influence vitamin D status on a population level. The purpose of our study was to compare 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized because of severe COVID-19 during two waves of the pandemic (2020/21 vs. 2021/22).Materials and methods: We analyzed 101 patients (61 males/ 40 females) hospitalized in the internal medicine department of...

Introduction and aims: Association between coronary artery disease (CAD) and male gonadal status has been previously suggested, but still remains inconclusive. Aims of our study in males with recent acute coronary syndrome (ACS) were to evaluate the prevalence of hypogonadism, to compare their gonadal status with non-ACS matched controls and to evaluate gonadal status by the extent of CAD.Subjects and Methods: A cross-sectional retrospective study includ...

Introduction: Osteoporosis is known chronic complication of inflammatory bowel diseases (IBD). It is known that areal bone mineral density (aBMD) does not sufficiently reflect bone strength and quality. The trabecular bone score (TBS) provides an indirect measurement of bone microarchitecture, independent of aBMD.Aims and methods: The aim was to assess TBS in IBD patients with regard to disease behavior using in comparison with lumbar spine (LS) BMD. The...

There have been many discussions about testosterone role in inflammation and autoimmunity. Inflammatory bowel disease (IBD) is a chronic autoimmune disease in younger age groups. The aim ouf our study was to evaluate testosterone concentration and it’s influence on disease acitivity and the quality of life.In our cross-sectional study we measured total testosterone levels in males with IBD (Crohn’s Disease, Ulcerative colitis). Age, BMI, main c...

Background: Hyponatremia is the most common electrolyte abnormality, it increases morbidity and mortality, but it is not clear if this condition influences mortality independently of other contributing factors. The aim of our study was to assess the relative contribution of hyponatremia to in-hospital mortality and to determine predictive factors associated with hyponatremia-related mortality.Materials and methods: A database search was conducted for all...

Background: GH plays an important role in maintaining physiological morphology and function of the left ventricle (LV). In GH deficient (GHD) patients a systolic and/or diastolic LV dysfunction has been documented. LV systolic dysfunction results from reduced LV mass (LVM), which subsequently leads to a decrease of the LV ejection fraction (EF). Results from clinical trials evaluating the effect of GH replacement therapy on the morphological and functional changes of the LV in...

Introduction: Teriparatide (TPTD) is a recombinant aminoterminal fragment (1–34) of the human parathyroid hormone (PTH), which has a predominantly stimulating effect on bone formation. We report results of an 18-month prospective multicenter study with daily s.c. application of 20 μg of teriparatide in 85 elderly women with severe osteoporosis, the efficacy, safety and compliance of the treatment.Outcomes: The primary outcomes were defined as c...